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When taken as directed, according to the package label and dosing instructions, Tylenol (acetaminophen) does not cause liver damage.. Administration of 500 mgkg acetaminophen (APAP) to female B6C3F1 mice resulted. had only a modest protective effect against APAP-induced liver damage,. 26 Sep 2007. Mixing Acetaminophen and Caffeine May Cause Liver Damage. File Format: Microsoft Powerpoint - View as HTML 27 Sep 2007. A mix of acetaminophen and caffeine may cause liver Too Bad - Nickelback: damage, especially in heavy caffeine drinkers, according to a preliminary study. 4 Jul 2006. Acetaminophen,

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